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The antibody against TFR2 was raised in rabbit using the Recombinant Human Transferrin receptor protein 2 protein (534-605AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TFR2 was raised in rabbit using the Recombinant Human Transferrin receptor protein 2 protein (534-605AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-04975A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TFR2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transferrin receptor protein 2 protein (534-605AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UP52 |
Uniprot Id
Q9UP52
Target Species
Human
Target Name
TFR2
Target Full Name
Transferrin receptor protein 2
Target Function
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Target Involvement
Hemochromatosis 3 (HFE3)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.; [Isoform Beta]: Cytoplasm. Note=Lacks the transmembrane domain. Probably intracellular.
Target Protein Families
Peptidase M28 family, M28B subfamily
Target Tissue Specificity
Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.
Target Synonyms
HFE 3; HFE3; MGC126368; TFR 2; TfR2; TFR2_HUMAN; TFRC 2; TFRC2; Transferrin receptor 2; Transferrin receptor protein 2
Target Background
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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