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The antibody against THG1L was raised in rabbit using the Human THG1L as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against THG1L was raised in rabbit using the Human THG1L as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-46936A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | THG1L |
| Target Synonyms | THG1L antibody; ICF45 antibody; Probable tRNA(His) guanylyltransferase antibody; EC 2.7.7.79 antibody; Interphase cytoplasmic foci protein 45 antibody; tRNA-histidine guanylyltransferase antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human THG1L | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NWX6 |
Uniprot Id
Q9NWX6
Target Species
Human
Target Name
THG1L
Target Full Name
Probable tRNA(His) guanylyltransferase
Target Function
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.
Target Subcellular Location
Cytoplasm. Mitochondrion outer membrane.
Target Protein Families
TRNA(His) guanylyltransferase family
Target Tissue Specificity
Expressed in many tissues.
Target Synonyms
THG1L; ICF45; Probable tRNA(His) guanylyltransferase; EC 2.7.7.79; Interphase cytoplasmic foci protein 45; tRNA-histidine guanylyltransferase
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