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The antibody against Thioredoxin 2 (Trx2/TXN2) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human Thioredoxin 2 (Trx2/Thioredoxin 2 (Trx2/TXN2)) (NP_036605.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against Thioredoxin 2 (Trx2/TXN2) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human Thioredoxin 2 (Trx2/Thioredoxin 2 (Trx2/TXN2)) (NP_036605.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02846A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Thioredoxin 2 (Trx2/TXN2) |
| Target Synonyms | TXN; MTRX; TRX2; MT-TRX; COXPD29; Thioredoxin 2 (Trx2/TXN2) | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Raji, SW620, THP-1 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human Thioredoxin 2 (Trx2/Thioredoxin 2 (Trx2/TXN2)) (NP_036605.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG | Uniprot ID | Q99757 |
Uniprot Id
Q99757
Target Species
Human
Target Name
TXN2
Target Full Name
Thioredoxin, mitochondrial
Target Function
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Target Involvement
Combined oxidative phosphorylation deficiency 29 (COXPD29)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Thioredoxin family
Target Tissue Specificity
Widely expressed in adult (at protein level) and fetal tissues.
Target Research Area
Signal Transduction
Target Synonyms
TXN2; TRX2; Thioredoxin; mitochondrial; MTRX; Mt-Trx; Thioredoxin-2
Target Background
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
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