Rabbit anti-Human THOC7 Polyclonal Antibody

Uniprot Id

Q6I9Y2

Target Species

Human

Target Name

THOC7

Target Full Name

THO complex subunit 7

Target Function

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.; The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Target Subcellular Location

Cytoplasm. Nucleus. Nucleus speckle.

Target Protein Families

THOC7 family

Target Synonyms

FLJ23445; fSAP24; Functional spliceosome associated protein 24; Functional spliceosome-associated protein 24; hTREX30; Ngg1 interacting factor 3 like 1 binding protein 1; Ngg1 interacting factor 3 like protein 1 binding protein 1; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1 binding protein 1; NIF3L1-binding protein 1; NIF3L1BP1; THO complex 7 homolog (Drosophila); THO complex 7 homolog; THO complex subunit 7 homolog; THOC 7; thoc7; THOC7_HUMAN

Target Background

Predicted to enable RNA binding activity. Involved in mRNA export from nucleus and viral mRNA export from host cell nucleus. Located in cytosol and nuclear speck. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region.