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The antibody against TIAM2 was raised in rabbit using the Recombinant Human T-lymphoma invasion and metastasis-inducing protein 2 protein (1500-1627AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TIAM2 was raised in rabbit using the Recombinant Human T-lymphoma invasion and metastasis-inducing protein 2 protein (1500-1627AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-02947A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TIAM2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human T-lymphoma invasion and metastasis-inducing protein 2 protein (1500-1627AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IVF5 |
Uniprot Id
Q8IVF5
Target Species
Human
Target Name
TIAM2
Target Full Name
Rho guanine nucleotide exchange factor TIAM2
Target Function
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
Target Subcellular Location
Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Cell projection, neuron projection. Perikaryon.
Target Protein Families
TIAM family
Target Tissue Specificity
Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
Target Synonyms
FLJ41865; OTTHUMP00000017472; SIF and TIAM1 like exchange factor ; SIF and TIAM1-like exchange factor; STEF ; T cell lymphoma invasion and metastasis 2; T lymphoma invasion and metastasis inducing protein 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM 2; TIAM-2; Tiam2; TIAM2_HUMAN
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