Rabbit anti-Human TIMM10B Polyclonal Antibody

Uniprot Id

Q9Y5J6

Target Species

Human

Target Name

TIMM10B

Target Full Name

Mitochondrial import inner membrane translocase subunit Tim10 B

Target Function

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein.

Target Protein Families

Small Tim family

Target Tissue Specificity

Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Target Research Area

Signal Transduction

Target Synonyms

Fracture callus 1 homolog (rat); Fracture callus 1 homolog; Fracture callus protein 1; FxC1; Mitochondrial import inner membrane translocase subunit Tim10 B; Mitochondrial import inner membrane translocase subunit Tim9 B; OTTHUMP00000164584; OTTHUMP00000230720; TIM 10B; Tim10b; Tim9b; TIM9B_HUMAN; TIMM10B; Translocase of inner mitochondrial membrane 10 homolog B (yeast)

Target Background

FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.