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The antibody against TIMP4 was raised in rabbit using the Synthesized peptide derived from C-terminal of Human TIMP4. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against TIMP4 was raised in rabbit using the Synthesized peptide derived from C-terminal of Human TIMP4. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TIMP4 antibody.
Western blot analysis of extracts from NIH/3T3 cells, using TIMP4 antibody.2
Western blot analysis of extracts from HepG2 cells (Lane 2), using TIMP4 antiobdy. The lane on the left is treated with synthesized peptide.3
| Cat.No | ADC-42283A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TIMP4 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from C-terminal of Human TIMP4. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99727 |
Uniprot Id
Q99727
Target Species
Human
Target Name
TIMP4
Target Full Name
Metalloproteinase inhibitor 4
Target Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Target Subcellular Location
Secreted.
Target Protein Families
Protease inhibitor I35 (TIMP) family
Target Tissue Specificity
Abundant in heart and present at low levels in many other tissues.
Target Research Area
Cancer, Cardiovascular
Target Synonyms
Metalloproteinase inhibitor 4; TIMP 4; TIMP metallopeptidase inhibitor 4; TIMP-4; Timp4; TIMP4_HUMAN; Tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4
Target Background
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
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