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The antibody against TIPRL was raised in rabbit using the Recombinant Human TIP41-like protein (1-178AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against TIPRL was raised in rabbit using the Recombinant Human TIP41-like protein (1-178AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-23299A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TIPRL |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human TIP41-like protein (1-178AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75663 |
Uniprot Id
O75663
Target Species
Human
Target Name
TIPRL
Target Full Name
TIP41-like protein
Target Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TIP41 family
Target Synonyms
1810011K17Rik; dJ69E11.3; MGC3794; Putative MAPK activating protein PM10; Putative MAPK-activating protein PM10; RP1-69E11.1; Tip; TIP41; TIP41-like protein; tiprl; TIPRL_HUMAN; TOR signaling pathway regulator; TOR Signaling Pathway Regulator like; Type 2A-interacting protein
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