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The antibody against TM4SF20 was raised in rabbit using the Recombinant Human Transmembrane 4 L6 family member 20 protein (114-184AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TM4SF20 was raised in rabbit using the Recombinant Human Transmembrane 4 L6 family member 20 protein (114-184AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using TM4SF20 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using TM4SF20 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-14328A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TM4SF20 |
| Target Synonyms | TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transmembrane 4 L6 family member 20 protein (114-184AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q53R12 |
Uniprot Id
Q53R12
Target Species
Human
Target Name
TM4SF20
Target Full Name
Transmembrane 4 L6 family member 20
Target Function
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
Target Involvement
Specific language impairment 5 (SLI5)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
L6 tetraspanin family
Target Tissue Specificity
Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum.
Target Synonyms
TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20
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