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The antibody against TM4SF5 was raised in rabbit using the Recombinant Human Transmembrane 4 L6 family member 5 protein (112-157AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TM4SF5 was raised in rabbit using the Recombinant Human Transmembrane 4 L6 family member 5 protein (112-157AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using TM4SF5 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using TM4SF5 Antibody at dilution of 1:1002
| Cat.No | ADC-21307A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TM4SF5 |
| Target Synonyms | TM4SF5 antibody; Transmembrane 4 L6 family member 5 antibody; Tetraspan transmembrane protein L6H antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transmembrane 4 L6 family member 5 protein (112-157AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14894 |
Uniprot Id
O14894
Target Species
Human
Target Name
TM4SF5
Target Full Name
Transmembrane 4 L6 family member 5
Target Function
Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression.
Target Subcellular Location
Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
L6 tetraspanin family
Target Tissue Specificity
Intestine. Overexpressed in pancreatic cancers.
Target Synonyms
TM4SF5; Transmembrane 4 L6 family member 5; Tetraspan transmembrane protein L6H
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