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The antibody against TMEM27 was raised in rabbit using the Recombinant Human Collectrin protein (15-141AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TMEM27 was raised in rabbit using the Recombinant Human Collectrin protein (15-141AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using TMEM27 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using TMEM27 Antibody at dilution of 1:1002
Immunofluorescent analysis of MCF-7 cells using TMEM27 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-43871A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TMEM27 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Collectrin protein (15-141AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HBJ8 |
Uniprot Id
Q9HBJ8
Target Species
Human
Target Name
CLTRN
Target Full Name
Collectrin
Target Function
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
TMEM27 family
Target Tissue Specificity
Kidney; collecting ducts. Pancreas; beta cells of islets.
Target Synonyms
UNQ679; Collectrin; kidney-specific membrane protein; NX-17; NX17; PRO1312; Tmem27; TMM27_HUMAN; Transmembrane protein 27; UNQ679/PRO1312
Target Background
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells.
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