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The antibody against TMX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 128-296 of human TMX2 (NP_057043.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against TMX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 128-296 of human TMX2 (NP_057043.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-06064A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TMX2 |
| Target Synonyms | PIG26; CGI-31; PDIA12; NEDMCMS; TXNDC14; TMX2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, A-549, HepG2, Mouse brain, Mouse liver, Rat testis, U-251MG | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 128-296 of human TMX2 (NP_057043.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | KPPLYMGPEYIKYFNDKTIDEELERDKRVTWIVEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPTLILFQGGKEAMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQRAKKLSKAGDNIPEEQPVASTPTTVSDGENKKDK | Uniprot ID | Q9Y320 |
Uniprot Id
Q9Y320
Target Species
Human
Target Name
TMX2
Target Full Name
Thioredoxin-related transmembrane protein 2
Target Function
Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane.
Target Tissue Specificity
Widely expressed.
Target Research Area
Cell Biology
Target Synonyms
Cell proliferation inducing gene 26 protein; Cell proliferation-inducing gene 26 protein; CGI 31; Growth inhibiting gene 11; PDIA12; PIG26; Protein disulfide isomerase family A; member 12; Thioredoxin domain containing protein 14; Thioredoxin domain-containing protein 14; Thioredoxin related transmembrane protein 2; Thioredoxin-related transmembrane protein 2; tmx2; TMX2_HUMAN; TXNDC14
Target Background
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines.
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