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The antibody against TNFAIP8 was raised in rabbit using the Synthesized peptide derived from internal of Human TFIP8. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against TNFAIP8 was raised in rabbit using the Synthesized peptide derived from internal of Human TFIP8. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC, IF.
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Western blot analysis of extracts from HUVEC cells, using TFIP8 antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TFIP8 antibody.2
Immunofluorescence analysis of A549 cells, using TFIP8 antibody.3
| Cat.No | ADC-42190A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TNFAIP8 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human TFIP8. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95379 |
Uniprot Id
O95379
Target Species
Human
Target Name
TNFAIP8
Target Full Name
Tumor necrosis factor alpha-induced protein 8
Target Function
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TNFAIP8 family
Target Tissue Specificity
Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, l
Target Research Area
Apoptosis
Target Synonyms
GG2 1; Head and neck tumor and metastasis-related protein; MDC-3.13; NDED; NF-kappa-B-inducible DED-containing protein; SCC S2; SCC-S2; SCCS2; TFIP8_HUMAN; TNF alpha-induced protein 8; TNF induced protein; TNF-induced protein GG2-1; TNFAIP 8; TNFAIP8; Tumor necrosis factor alpha induced protein 8; Tumor necrosis factor alpha-induced protein 8
Target Background
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm.
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