Rabbit anti-Human TNFRSF6B Polyclonal Antibody

The antibody against TNFRSF6B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human TNFRSF6B (NP_003814.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-06514A

Number

Cat.No	ADA-06514A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TNFRSF6B
Target Synonyms	M68; TR6; DCR3; M68E; DJ583P15.1.1; TNFRSF6B	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-549, DU145, HepG2, SGC-7901, SW480	Application	ELISA, WB

Cat.No

ADA-06514A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TNFRSF6B

Target Synonyms

M68; TR6; DCR3; M68E; DJ583P15.1.1; TNFRSF6B

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-549, DU145, HepG2, SGC-7901, SW480

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human TNFRSF6B (NP_003814.1).	Target Species	Human
Immunogen Sequence	PLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH	Uniprot ID	O95407

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human TNFRSF6B (NP_003814.1).

Target Species

Human

Immunogen Sequence

PLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH

Uniprot ID

O95407

Background Information

Uniprot Id

O95407
Target Species

Human
Target Name

TNFRSF6B
Target Full Name

Tumor necrosis factor receptor superfamily member 6B
Target Function

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Target Subcellular Location

Secreted.
Target Tissue Specificity

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
Target Synonyms

DcR3; Decoy receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; M68E; OTTHUMP00000031583 ; TNF6B_HUMAN; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; Tumor necrosis factor receptor superfamily member 6b decoy; UNQ186/PRO212
Target Background

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.

Rabbit anti-Human TNFRSF6B Polyclonal Antibody

Specifications

Immunogen Information

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