Rabbit anti-Human TNPO1 Polyclonal Antibody

Uniprot Id

Q92973

Target Species

Human

Target Name

TNPO1

Target Full Name

Transportin-1

Target Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner.; (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Importin beta family, Importin beta-2 subfamily

Target Synonyms

Importin 2; Importin beta 2; Importin beta-2; IPO 2; IPO2; Karyopherin (importin) beta 2; Karyopherin beta 2; Karyopherin beta-2; KPN B2; KPNB 2; KPNB2; M9 interacting protein; M9 region interacting protein; M9 region interaction protein; MIP 1; MIP; MIP1; OTTHUMP00000126960; OTTHUMP00000222024; OTTHUMP00000226224; TNPO 1; Tnpo1; TNPO1_HUMAN; Transportin 1; Transportin; Transportin-1; Transportin1; TRN

Target Background

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins.