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The antibody against TOM70 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_055635.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against TOM70 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_055635.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-12335A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TOM70 |
| Target Synonyms | Tom70; TOMM70A; TOM70 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293T, Mouse brain, Rat liver, SH-SY5Y | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_055635.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O94826 | Immunogen Sequence |
Uniprot Id
O94826
Target Species
Human
Target Name
TOMM70
Target Full Name
Mitochondrial import receptor subunit TOM70
Target Function
Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.
Target Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein.
Target Protein Families
Tom70 family
Target Synonyms
TOMM70; KIAA0719; TOM70; TOMM70A; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70
Target Background
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins.
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