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The antibody against TOP2B was raised in rabbit using the Recombinant Human DNA topoisomerase 2-beta protein (1400-1626AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against TOP2B was raised in rabbit using the Recombinant Human DNA topoisomerase 2-beta protein (1400-1626AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-08747A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TOP2B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA topoisomerase 2-beta protein (1400-1626AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q02880 |
Uniprot Id
Q02880
Target Species
Human
Target Name
TOP2B
Target Full Name
DNA topoisomerase 2-beta
Target Function
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
Target Involvement
A defect in TOP2B is associated with autism spectrum disorder (ASD).
Target Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
Target Protein Families
Type II topoisomerase family
Target Tissue Specificity
Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung. Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas.
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