Rabbit anti-Human TP73 Polyclonal Antibody

Uniprot Id

O15350

Target Species

Human

Target Name

TP73

Target Full Name

Tumor protein p73

Target Function

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

Target Subcellular Location

Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.

Target Protein Families

P53 family

Target Tissue Specificity

Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Target Synonyms

p53 like transcription factor; p53 related protein; p53-like transcription factor; p53-related protein; p73; P73_HUMAN; TP73; Tumor protein p73

Target Background

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.