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The antibody against TPH2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-170 of human TPH2 (NP_775489.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TPH2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-170 of human TPH2 (NP_775489.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09366A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TPH2 |
| Target Synonyms | NTPH; ADHD7; TPH2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse skeletal muscle | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-170 of human TPH2 (NP_775489.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLM | Uniprot ID | Q8IWU9 |
Uniprot Id
Q8IWU9
Target Species
Human
Target Name
TPH2
Target Full Name
Tryptophan 5-hydroxylase 2
Target Involvement
Major depressive disorder (MDD); Attention deficit-hyperactivity disorder 7 (ADHD7)
Target Protein Families
Biopterin-dependent aromatic amino acid hydroxylase family
Target Tissue Specificity
Brain specific.
Target Research Area
Neuroscience
Target Synonyms
TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
Target Background
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
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