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The antibody against TPO was raised in rabbit using the Recombinant Human Thyroid peroxidase protein (19-846AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TPO was raised in rabbit using the Recombinant Human Thyroid peroxidase protein (19-846AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human thyroid tissue using TPO Antibody at dilution of 1:100
| Cat.No | ADC-44944A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TPO |
| Target Synonyms | MSA antibody; PERT_HUMAN antibody; TDH2A antibody; Thyroid microsomal antigen antibody; Thyroid peroxidase antibody; Thyroperoxidase antibody; TPO antibody; TPX antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Thyroid peroxidase protein (19-846AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07202 |
Uniprot Id
P07202
Target Species
Human
Target Name
TPO
Target Full Name
Thyroid peroxidase
Target Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Target Involvement
Thyroid dyshormonogenesis 2A (TDH2A)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
Target Protein Families
Peroxidase family, XPO subfamily
Target Research Area
Cancer
Target Synonyms
MSA ; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX
Target Background
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
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