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The antibody against TPSAB1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 31-275 of human TPSAB1 (NP_003285.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TPSAB1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 31-275 of human TPSAB1 (NP_003285.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04428A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Tpsab1 |
| Target Synonyms | TPS1; TPS2; TPSB1; TPSB2; Tryptase-2; TPSAB1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse skin, Rat skin | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 31-275 of human TPSAB1 (NP_003285.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q15661 | Immunogen Sequence |
Uniprot Id
Q15661
Target Species
Human
Target Name
TPSAB1
Target Full Name
Tryptase alpha/beta-1
Target Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase S1 family, Tryptase subfamily
Target Tissue Specificity
Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surro
Target Synonyms
TPSAB1; TPS1; TPS2; TPSB1; Tryptase alpha/beta-1; Tryptase-1; EC 3.4.21.59; Tryptase I; Tryptase alpha-1
Target Background
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
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