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The antibody against TRAM2 was raised in rabbit using the Recombinant Human Translocating chain-associated membrane protein 2 protein (316-370AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TRAM2 was raised in rabbit using the Recombinant Human Translocating chain-associated membrane protein 2 protein (316-370AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human pancreatic cancer using TRAM2 Antibody at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using TRAM2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-20192A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRAM2 |
| Target Synonyms | TRAM2; KIAA0057; Translocating chain-associated membrane protein 2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Translocating chain-associated membrane protein 2 protein (316-370AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15035 |
Uniprot Id
Q15035
Target Species
Human
Target Name
TRAM2
Target Full Name
Translocating chain-associated membrane protein 2
Target Function
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
TRAM family
Target Synonyms
TRAM2; KIAA0057; Translocating chain-associated membrane protein 2
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