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The antibody against TRIB2 was raised in rabbit using the Recombinant Human Tribbles homolog 2 protein (204-337AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TRIB2 was raised in rabbit using the Recombinant Human Tribbles homolog 2 protein (204-337AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human placenta tissue using TRIB2 Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using TRIB2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-09550A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIB2 |
| Target Synonyms | C5FW antibody; FLJ57420 antibody; GS3955 antibody; Hypothetical protein TRB2 antibody; TRB-2 antibody; TRB2 antibody; TRIB 2 antibody; TRIB2 antibody; TRIB2_HUMAN antibody; Tribbles homolog 2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tribbles homolog 2 protein (204-337AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q92519 |
Uniprot Id
Q92519
Target Species
Human
Target Name
TRIB2
Target Full Name
Tribbles homolog 2
Target Function
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton.
Target Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily
Target Tissue Specificity
Highly expressed in peripheral blood leukocytes.
Target Synonyms
C5FW; FLJ57420; GS3955; Hypothetical protein TRB2; TRB-2; TRB2; TRIB 2; TRIB2; TRIB2_HUMAN; Tribbles homolog 2
Target Background
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
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