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The antibody against TRIM2 was raised in rabbit using the Human TRIM2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IF.
The antibody against TRIM2 was raised in rabbit using the Human TRIM2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IF.
$600.00
| Cat.No | ADC-51515A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM2 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Human TRIM2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9C040 |
Uniprot Id
Q9C040
Target Species
Human
Target Name
TRIM2
Target Full Name
Tripartite motif-containing protein 2
Target Function
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Target Involvement
Charcot-Marie-Tooth disease 2R (CMT2R)
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRIM/RBCC family
Target Synonyms
E3 ubiquitin protein ligase TRIM2; KIAA0517; RING finger protein 86; RNF86; Trim2; TRIM2_HUMAN; Tripartite motif containing 2; Tripartite motif protein 2; Tripartite motif protein TRIM2; Tripartite motif-containing 2; Tripartite motif-containing protein 2
Target Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.
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