Rabbit anti-Human TRIM39 Polyclonal Antibody

The antibody against TRIM39 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 350-450 of human TRIM39 (NP_067076.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00835A

Number

Cat.No	ADA-00835A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TRIM39
Target Synonyms	TFP; RNF23; TRIM39B; TRIM39	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, K-562, LO2, MCF7, SW480	Application	ELISA, WB

Cat.No

ADA-00835A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TRIM39

Target Synonyms

TFP; RNF23; TRIM39B; TRIM39

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, K-562, LO2, MCF7, SW480

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TRIM39 (NP_067076.2).	Target Species	Human
Immunogen Sequence	LVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLH	Uniprot ID	Q9HCM9

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TRIM39 (NP_067076.2).

Target Species

Human

Immunogen Sequence

LVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLH

Uniprot ID

Q9HCM9

Background Information

Uniprot Id

Q9HCM9
Target Species

Human
Target Name

TRIM39
Target Full Name

E3 ubiquitin-protein ligase TRIM39
Target Function

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.; Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner.
Target Subcellular Location

[Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus.; [Isoform 2]: Nucleus.
Target Protein Families

TRIM/RBCC family
Target Tissue Specificity

Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
Target Synonyms

HGNC:10065; MGC32984; RING finger protein 23; RNF23; Testis abundant finger protein; Testis-abundant finger protein; TFP; TFP RING FINGER PROTEIN 23; TRI39_HUMAN; Trim39; TRIM39B; Tripartite motif containing 39; Tripartite motif-containing protein 39
Target Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms.

Rabbit anti-Human TRIM39 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human TRIM39 Polyclonal Antibody Now

Related Products