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The antibody against TRIM62 was raised in rabbit using the Synthetic peptide of Human TRIM62 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against TRIM62 was raised in rabbit using the Synthetic peptide of Human TRIM62 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-25680A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM62 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human TRIM62 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BVG3 |
Uniprot Id
Q9BVG3
Target Species
Human
Target Name
TRIM62
Target Full Name
E3 ubiquitin-protein ligase TRIM62
Target Function
E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRIM/RBCC family
Target Synonyms
6330414G21Rik; AI450348; DEAR1; ductal epithelium-associated RING Chromosome 1; E3 ubiquitin-protein ligase TRIM62; FLJ10759; FLJ16558 ; MGC115263; TRI62_HUMAN; TRIM62; Tripartite motif containing 62; Tripartite motif-containing protein 62
Target Background
Enables identical protein binding activity; transcription coactivator activity; and ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of antifungal innate immune response. Is active in cytoplasm.
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