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The antibody against TRIM71 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase TRIM71 protein (125-209AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TRIM71 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase TRIM71 protein (125-209AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-06614A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM71 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase TRIM71 protein (125-209AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q2Q1W2 |
Uniprot Id
Q2Q1W2
Target Species
Human
Target Name
TRIM71
Target Full Name
E3 ubiquitin-protein ligase TRIM71
Target Function
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression.
Target Subcellular Location
Cytoplasm, P-body.
Target Protein Families
TRIM/RBCC family
Target Tissue Specificity
Specifically expressed in testis.
Target Synonyms
2610206G21Rik; Abnormal cell LINeage LIN 41; AL022943; E3 ubiquitin-protein ligase TRIM71; Gm1127; Homolog of C. elegans Lin 41; LIN 41; LIN41; LIN41_HUMAN; mlin 41; Protein lin 41 homolog; Protein lin-41 homolog; RGD1566388; Ripply2; TRIM 71; TRIM71; Tripartite motif containing 71; Tripartite motif-containing protein 71
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