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The antibody against TRMT112 was raised in rabbit using the Recombinant Human tRNA methyltransferase 112 homolog protein (1-125AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TRMT112 was raised in rabbit using the Recombinant Human tRNA methyltransferase 112 homolog protein (1-125AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lung cancer using TRMT112 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human melanoma using TRMT112 Antibody at dilution of 1:1002
| Cat.No | ADC-49635A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRMT112 |
| Target Synonyms | TRMT112 antibody; AD-001 antibody; HSPC152 antibody; HSPC170 antibody; Multifunctional methyltransferase subunit TRM112-like protein antibody; tRNA methyltransferase 112 homolog antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human tRNA methyltransferase 112 homolog protein (1-125AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UI30 |
Uniprot Id
Q9UI30
Target Species
Human
Target Name
TRMT112
Target Full Name
Multifunctional methyltransferase subunit TRM112-like protein
Target Function
Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with HEMK2/N6AMT1 also monomethylates 'Lys-12' of histone H4 (H4K12me1). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA.
Target Subcellular Location
Nucleus, nucleoplasm. Cytoplasm, perinuclear region.
Target Protein Families
TRM112 family
Target Synonyms
TRMT112; AD-001; HSPC152; HSPC170; Multifunctional methyltransferase subunit TRM112-like protein; tRNA methyltransferase 112 homolog
Target Background
Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex.
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