Rabbit anti-Human Troponin I2 (TNNI2) Polyclonal Antibody

Uniprot Id

P48788

Target Species

Human

Target Name

TNNI2

Target Full Name

Troponin I, fast skeletal muscle

Target Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Target Involvement

Arthrogryposis, distal, 2B (DA2B)

Target Protein Families

Troponin I family

Target Synonyms

AMCD 2B; AMCD2B; DA 2B; DA2B; fast skeletal muscle; Fast twitch skeletal muscle troponin I; fast-twitch isoform; FSSV; fsTnI; TNNI 2; Tnni2; TNNI2_HUMAN; tro; Troponin I; Troponin I fast skeletal muscle; Troponin I fast twitch 2; Troponin I fast twitch isoform; Troponin I fast twitch skeletal muscle isoform; Troponin I skeletal fast; Troponin I type 2 (skeletal fast); Troponin I type 2

Target Background

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.