Rabbit anti-Human TRPC5 Polyclonal Antibody

Uniprot Id

Q9UL62

Target Species

Human

Target Name

TRPC5

Target Full Name

Short transient receptor potential channel 5

Target Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC5 sub-subfamily

Target Tissue Specificity

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.

Target Synonyms

Htrp 5; Htrp-5; Htrp5; Short transient receptor potential channel 5; Transient receptor potential cation channel subfamily C member 5; Transient receptor potential channel 5; Transient receptor protein 5; TRP 5; TRP-5; TRP5; TRPC 5; TrpC5; TRPC5_HUMAN

Target Background

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).