Rabbit anti-Human TRPS1 Polyclonal Antibody

Uniprot Id

Q9UHF7

Target Species

Human

Target Name

TRPS1

Target Full Name

Zinc finger transcription factor Trps1

Target Function

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.

Target Involvement

Tricho-rhino-phalangeal syndrome 1 (TRPS1); Tricho-rhino-phalangeal syndrome 2 (TRPS2); Tricho-rhino-phalangeal syndrome 3 (TRPS3)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.

Target Synonyms

GC79; LGCR; Transcriptional repressor GATA binding 1; Tricho rhino phalangeal syndrome I; Tricho-rhino-phalangeal syndrome type I protein; Trichorhinophalangeal syndrome I; Trichorhinophalangeal syndrome I homolog; TRPS 1; trpS1; TRPS1 gene; TRPS1_HUMAN; Zinc finger protein GC79; Zinc finger transcription factor TRPS 1; Zinc finger transcription factor Trps1

Target Background

This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III.