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The antibody against TSEN15 was raised in rabbit using the Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TSEN15 was raised in rabbit using the Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-04721A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TSEN15 |
| Target Synonyms | TSEN15 antibody; C1orf19 antibody; SEN15 antibody; tRNA-splicing endonuclease subunit Sen15 antibody; SEN15 homolog antibody; HsSEN15 antibody; tRNA-intron endonuclease Sen15 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WW01 |
Uniprot Id
Q8WW01
Target Species
Human
Target Name
TSEN15
Target Full Name
tRNA-splicing endonuclease subunit Sen15
Target Function
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
Target Involvement
Pontocerebellar hypoplasia 2F (PCH2F)
Target Subcellular Location
Nucleus. Nucleus, nucleolus.
Target Protein Families
SEN15 family
Target Tissue Specificity
Widely expressed. Highly expressed in testis and uterus.
Target Synonyms
TSEN15; C1orf19; SEN15; tRNA-splicing endonuclease subunit Sen15; SEN15 homolog; HsSEN15; tRNA-intron endonuclease Sen15
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