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The antibody against TSHR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-253 of human TSHR (NP_001018046.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against TSHR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-253 of human TSHR (NP_001018046.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-11998A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TSHR |
| Target Synonyms | LGR3; CHNG1; hTSHR-I; TSHR | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat kidney | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 21-253 of human TSHR (NP_001018046.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P16473 | Immunogen Sequence |
Uniprot Id
P16473
Target Species
Human
Target Name
TSHR
Target Full Name
Thyrotropin receptor
Target Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Target Involvement
Hypothyroidism, congenital, non-goitrous, 1 (CHNG1); Familial gestational hyperthyroidism (HTFG); Hyperthyroidism, non-autoimmune (HTNA)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Target Tissue Specificity
Expressed in thyroide cells (at protein level). Expressed in the thyroid.
Target Synonyms
LGR3; CHNG1; hTSHR-I; TSHR
Target Background
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
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