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The antibody against TSHZ3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 791-890 of human TSHZ3 (NP_065907.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TSHZ3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 791-890 of human TSHZ3 (NP_065907.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03597A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TSHZ3 |
| Target Synonyms | TSH3; ZNF537; TSHZ3 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 791-890 of human TSHZ3 (NP_065907.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | DLTKGKSDKGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQK | Uniprot ID | Q63HK5 |
Uniprot Id
Q63HK5
Target Species
Human
Target Name
TSHZ3
Target Full Name
Teashirt homolog 3
Target Function
Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation
Target Involvement
TSHZ3 haploinsufficiency due to proximal chromosome 19q13.11 deletions causes a neurodevelopmental disorder characterized by developmental delay, absent or delayed speech, intellectual disability, and autistic features. Some patients may have reanal tract abnormalities.
Target Subcellular Location
Nucleus. Cell projection, growth cone.
Target Protein Families
Teashirt C2H2-type zinc-finger protein family
Target Tissue Specificity
Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. Expressed in the fetal neocortex.
Target Synonyms
KIAA1474; Teashirt homolog 3; TSH3; TSH3_HUMAN; TSHZ3; Zinc finger protein 537
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