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The antibody against TSPAN33 was raised in rabbit using the Recombinant Human Tetraspanin-33 protein (118-235AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TSPAN33 was raised in rabbit using the Recombinant Human Tetraspanin-33 protein (118-235AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human gastric cancer using TSPAN33 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using TSPAN33 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-19519A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TSPAN33 |
| Target Synonyms | TSPAN33; PEN; Tetraspanin-33; Tspan-33; Penumbra; hPen; Proerythroblast new membrane | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tetraspanin-33 protein (118-235AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86UF1 |
Uniprot Id
Q86UF1
Target Species
Human
Target Name
TSPAN33
Target Full Name
Tetraspanin-33
Target Function
Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Cytoplasm.
Target Protein Families
Tetraspanin (TM4SF) family
Target Tissue Specificity
Predominantly expressed in erythroblasts.
Target Synonyms
TSPAN33; PEN; Tetraspanin-33; Tspan-33; Penumbra; hPen; Proerythroblast new membrane
Target Background
Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex.
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