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The antibody against TTI1 was raised in rabbit using the Recombinant Human TELO2-interacting protein 1 homolog protein (692-858AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TTI1 was raised in rabbit using the Recombinant Human TELO2-interacting protein 1 homolog protein (692-858AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human heart tissue using TTI1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using TTI1 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using TTI1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-14706A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTI1 |
| Target Synonyms | TTI1 antibody; KIAA0406 antibody; SMG10 antibody; TELO2-interacting protein 1 homolog antibody; Protein SMG10 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human TELO2-interacting protein 1 homolog protein (692-858AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43156 |
Uniprot Id
O43156
Target Species
Human
Target Name
TTI1
Target Full Name
TELO2-interacting protein 1 homolog
Target Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Tti1 family
Target Tissue Specificity
Widely expressed.
Target Synonyms
TTI1; KIAA0406; SMG10; TELO2-interacting protein 1 homolog; Protein SMG10
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