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The antibody against TTK was raised in rabbit using the Synthesized non-phosphopeptide derived from Human TTK around the phosphorylation site of threonine 676 (D-T-T(p)-S-V). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against TTK was raised in rabbit using the Synthesized non-phosphopeptide derived from Human TTK around the phosphorylation site of threonine 676 (D-T-T(p)-S-V). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TTK (Ab-676) antibody.
Western blot analysis of extracts from HUVEC cells, treated with etoposide (25uM, 24hours), using TTK (Ab-676) antibody.2
Western blot analysis of extracts from colo cells (Lane 2), using TTK (Ab-676) antiobdy. The lane on the left is treated with synthesized peptide.3
| Cat.No | ADC-42530A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTK |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized non-phosphopeptide derived from Human TTK around the phosphorylation site of threonine 676 (D-T-T(p)-S-V). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P33981 |
Uniprot Id
P33981
Target Species
Human
Target Name
TTK
Target Full Name
Dual specificity protein kinase TTK
Target Function
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Phosphorylates MAD1L1 to promote mitotic checkpoint signaling. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
Target Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Target Tissue Specificity
Present in rapidly proliferating cell lines.
Target Synonyms
cancer/testis antigen 96; CT96; Dual specificity protein kinase TTK; ECSTY kinase; ESK; FLJ38280; hMPS1; Monopolar Spindle 1 Like 1; MPH1; Mps 1; MPS1L1; Phosphotyrosine Picked Threonine Kinase; Phosphotyrosine picked threonine-protein kinase; PYT; RP3-357D13.2; ttk; TTK Protein Kinase; TTK_HUMAN
Target Background
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
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