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The antibody against TTLL8 was raised in rabbit using the Recombinant Human Protein monoglycylase TTLL8 protein (671-822AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TTLL8 was raised in rabbit using the Recombinant Human Protein monoglycylase TTLL8 protein (671-822AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lung tissue using TTLL8 Antibody at dilution of 1:100
Immunofluorescent analysis of Ntera-2 cells using TTLL8 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-14493A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTLL8 |
| Target Synonyms | TTLL8 antibody; Protein monoglycylase TTLL8 antibody; EC 6.3.2.- antibody; Tubulin--tyrosine ligase-like protein 8 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein monoglycylase TTLL8 protein (671-822AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A6PVC2 |
Uniprot Id
A6PVC2
Target Species
Human
Target Name
TTLL8
Target Full Name
Protein monoglycylase TTLL8
Target Function
Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine to the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins. Not involved in elongation step of the polyglycylation reaction. Preferentially monoglycylates alpha-tubulin over beta-tubulin. Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance. Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility. Monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Target Synonyms
TTLL8; Protein monoglycylase TTLL8; EC 6.3.2.-; Tubulin--tyrosine ligase-like protein 8
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