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The antibody against TUBB3 was raised in mouse using the Synthetic Peptide as the immunogen. This antibody exists as a non-conjugated isotype IgG. This antibody has been validated on ELISA, WB, IHC, IF, IP.
The antibody against TUBB3 was raised in mouse using the Synthetic Peptide as the immunogen. This antibody exists as a non-conjugated isotype IgG. This antibody has been validated on ELISA, WB, IHC, IF, IP.
$167.00
1) Input: Mouse Brain Tissue Lysate | 2) IP product: IP dilute 1: 200
IHC Staining of Human colon tissue, diluted at 1:200.2
Western blot analysis of 1) Hela, 2) Mouse Kidney tissue, 3) Rat Heart tissue, diluted at 1:5000.3
| Cat.No | ADC-55650A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | TUBB3 |
| Form | Liquid | Species Reactivity | Ch, Dg, H, Hm, M, Mk, R, Rb |
| Isotype | IgG | Storage Buffer | PH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol., PBS |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB, IP |
| Storage | Upon receipt |
| Immunogen Description | Synthetic Peptide | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13509 |
Uniprot Id
Q13509
Target Species
Human
Target Name
TUBB3
Target Full Name
Tubulin beta-3 chain
Target Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.
Target Involvement
Fibrosis of extraocular muscles, congenital, 3A (CFEOM3A); Cortical dysplasia, complex, with other brain malformations 1 (CDCBM1)
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
Target Protein Families
Tubulin family
Target Tissue Specificity
Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.
Target Research Area
Signal Transduction
Target Synonyms
beta 3 tubulin; beta 4; beta-4; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; M(beta)3; M(beta)6; MC1R; Neuron specific beta III Tubulin; Neuron-specific class III beta-tubulin; QccE-11995; QccE-15186; TBB3_HUMAN; Tubb 3; TUBB3; TUBB4; Tubulin beta 3 ; Tubulin beta 3 chain; Tubulin beta 4 ; Tubulin beta III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III; tuj 1; tuj1
Target Background
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
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