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The antibody against TUFM was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 186-455 of human TUFM (NP_003312.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, IP, ELISA.
The antibody against TUFM was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 186-455 of human TUFM (NP_003312.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, IP, ELISA.
| Cat.No | ADA-12240A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TUFM |
| Target Synonyms | P43; EFTU; COXPD4; EF-TuMT; TUFM | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Jurkat | Application | ELISA, WB, IF/ICC, IHC-P, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 186-455 of human TUFM (NP_003312.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P49411 | Immunogen Sequence |
Uniprot Id
P49411
Target Species
Human
Target Name
TUFM
Target Full Name
Elongation factor Tu, mitochondrial
Target Function
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
Target Involvement
Combined oxidative phosphorylation deficiency 4 (COXPD4)
Target Subcellular Location
Mitochondrion.
Target Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
Target Research Area
Metabolism, Epigenetics and Nuclear Signaling
Target Synonyms
COXPD4; EF Tu; EF TuMT; EF-Tu; EF-TuMT; EFTu; EFTU_HUMAN; EFTuMT; Elongation factor Tu; Elongation factor Tu mitochondrial; mitochondrial; P43; Tu translation elongation factor; mitochondrial; Tufm
Target Background
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17.
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