Rabbit anti-Human TXNL4A Polyclonal Antibody

The antibody against TXNL4A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human TXNL4A (NP_006692.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01293A

Number

Cat.No	ADA-01293A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TXNL4A
Target Synonyms	BMKS; DIB1; DIM1; TXNL4; SNRNP15; U5-15kD; TXNL4A	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse kidney, HL-60, Jurkat, LO2, Mouse pancreas	Application	ELISA, WB

Cat.No

ADA-01293A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TXNL4A

Target Synonyms

BMKS; DIB1; DIM1; TXNL4; SNRNP15; U5-15kD; TXNL4A

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse kidney, HL-60, Jurkat, LO2, Mouse pancreas

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human TXNL4A (NP_006692.1).	Target Species	Human
Immunogen Sequence	MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY	Uniprot ID	P83876

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human TXNL4A (NP_006692.1).

Target Species

Human

Immunogen Sequence

MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY

Uniprot ID

P83876

Background Information

Uniprot Id

P83876
Target Species

Human
Target Name

TXNL4A
Target Full Name

Thioredoxin-like protein 4A
Target Function

Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Target Involvement

Burn-McKeown syndrome (BMKS)
Target Subcellular Location

Nucleus.
Target Protein Families

DIM1 family
Target Synonyms

TXNL4A; DIM1; TXNL4Thioredoxin-like protein 4A; DIM1 protein homolog; Spliceosomal U5 snRNP-specific 15 kDa protein; Thioredoxin-like U5 snRNP protein U5-15kD
Target Background

The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human TXNL4A Polyclonal Antibody

Specifications

Immunogen Information

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