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The antibody against UBA6 was raised in rabbit using the Recombinant Human Ubiquitin-like modifier-activating enzyme 6 protein (1-44AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against UBA6 was raised in rabbit using the Recombinant Human Ubiquitin-like modifier-activating enzyme 6 protein (1-44AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human brain tissue using UBA6 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using UBA6 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using UBA6 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-14489A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UBA6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ubiquitin-like modifier-activating enzyme 6 protein (1-44AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A0AVT1 |
Uniprot Id
A0AVT1
Target Species
Human
Target Name
UBA6
Target Full Name
Ubiquitin-like modifier-activating enzyme 6
Target Function
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Target Protein Families
Ubiquitin-activating E1 family
Target Tissue Specificity
Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.
Target Research Area
Cell Biology
Target Synonyms
E1-L2; FLJ10808; FLJ23367; Monocyte protein 4; MOP 4; MOP-4; MOP4; UBA 6; Uba6; UBA6 ubiquitin activating enzyme E1; UBA6_HUMAN; UBE1L2; Ubiquitin activating enzyme 6; Ubiquitin activating enzyme E1 like 2; Ubiquitin activating enzyme E1 like protein 2; Ubiquitin like modifier activating enzyme 6; Ubiquitin-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2; Ubiquitin-like modifier-activating enzyme 6
Target Background
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).
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