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The antibody against UBASH3A was raised in rabbit using the Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against UBASH3A was raised in rabbit using the Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
Immunofluorescent analysis of HepG2 cells using UBASH3A Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-08330A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UBASH3A |
| Target Synonyms | A antibody; Ubiquitin-associated and SH3 domain-containing protein A antibody; UBS3A_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P57075 |
Uniprot Id
P57075
Target Species
Human
Target Name
UBASH3A
Target Full Name
Ubiquitin-associated and SH3 domain-containing protein A
Target Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Tissue Specificity
Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
Target Synonyms
Cbl interacting protein 4; Cbl-interacting protein 4; CLIP4; STS 2; STS-2; Suppressor of T cell receptor signaling 2; Suppressor of T-cell receptor signaling 2; T cell ubiquitin ligand; T cell ubiquitin ligand protein; T-cell ubiquitin ligand 1; TULA; TULA-1; UBASH3A; ubiquitin associated and SH3 domain containing, A; Ubiquitin-associated and SH3 domain-containing protein A; UBS3A_HUMAN
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