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Rabbit anti-Human UBASH3A Polyclonal Antibody

The antibody against UBASH3A was raised in rabbit using the Synthesized peptide derived from the Internal region of Human TULA. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.

ADC-34683A

The antibody against UBASH3A was raised in rabbit using the Synthesized peptide derived from the Internal region of Human TULA. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.

$167.00

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Specifications


Cat.No ADC-34683A ClonalityPolyclonal
Host SpeciesRabbitTarget NameUBASH3A
Target SynonymsA antibody; Ubiquitin-associated and SH3 domain-containing protein A antibody; UBS3A_HUMAN antibodyFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerolPurification MethodThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ConjugateNon-conjugatedApplicationELISA, WB
StorageUpon receipt

Immunogen Information


Immunogen DescriptionSynthesized peptide derived from the Internal region of Human TULA.Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP57075
Background Information
  • Uniprot Id

    P57075

  • Target Species

    Human

  • Target Name

    UBASH3A

  • Target Full Name

    Ubiquitin-associated and SH3 domain-containing protein A

  • Target Function

    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

  • Target Subcellular Location

    Cytoplasm. Nucleus.

  • Target Tissue Specificity

    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.

  • Target Synonyms

    Cbl interacting protein 4; Cbl-interacting protein 4; CLIP4; STS 2; STS-2; Suppressor of T cell receptor signaling 2; Suppressor of T-cell receptor signaling 2; T cell ubiquitin ligand; T cell ubiquitin ligand protein; T-cell ubiquitin ligand 1; TULA; TULA-1; UBASH3A; ubiquitin associated and SH3 domain containing, A; Ubiquitin-associated and SH3 domain-containing protein A; UBS3A_HUMAN

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