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The antibody against UBN1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human UBN-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
The antibody against UBN1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human UBN-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
$167.00
| Cat.No | ADC-35452A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UBN1 |
| Target Synonyms | UBN1 antibody; Ubinuclein-1 antibody; HIRA-binding protein antibody; Protein VT4 antibody; Ubiquitously expressed nuclear protein antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human UBN-1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NPG3 |
Uniprot Id
Q9NPG3
Target Species
Human
Target Name
UBN1
Target Full Name
Ubinuclein-1
Target Function
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Target Subcellular Location
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Target Protein Families
Ubinuclein family
Target Tissue Specificity
Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Target Synonyms
UBN1; Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein
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