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The antibody against UBN1 was raised in rabbit using the Human UBN1-Specific as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against UBN1 was raised in rabbit using the Human UBN1-Specific as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-46497A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UBN1 |
| Target Synonyms | UBN1 antibody; Ubinuclein-1 antibody; HIRA-binding protein antibody; Protein VT4 antibody; Ubiquitously expressed nuclear protein antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human UBN1-Specific | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NPG3 |
Uniprot Id
Q9NPG3
Target Species
Human
Target Name
UBN1
Target Full Name
Ubinuclein-1
Target Function
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Target Subcellular Location
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Target Protein Families
Ubinuclein family
Target Tissue Specificity
Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Target Synonyms
UBN1; Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein
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