Rabbit anti-Human UBQLN4 Polyclonal Antibody

Uniprot Id

Q9NRR5

Target Species

Human

Target Name

UBQLN4

Target Full Name

Ubiquilin-4

Target Function

Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1. Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.

Target Subcellular Location

Nucleus. Cytoplasm. Chromosome. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome.

Target Tissue Specificity

Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

Target Synonyms

28S ribosomal protein S7; A1U; A1Up; AI663987; Ataxin 1 interacting ubiquitin like protein; Ataxin 1 ubiquitin like interacting protein A1U; Ataxin 1 ubiquitin like interacting protein; Ataxin-1 ubiquitin-like-interacting protein A1U; bMRP 27a; bMRP27a; C1orf6; CIP75; Connexin43 interacting protein of 75 kDa; MRP S7; RGD1308273; S7mt; UBIN; Ubiquilin 4; Ubiquilin-4; UBQL4_HUMAN; UBQLN4

Target Background

Enables K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in cellular response to DNA damage stimulus; negative regulation of double-strand break repair via homologous recombination; and regulation of cellular catabolic process. Located in several cellular components, including autophagosome; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with cytosolic proteasome complex and nuclear proteasome complex.