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The antibody against UBR1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Ubr1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against UBR1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Ubr1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of Jurkat cells using Ubr1 Polyclonal Antibody
| Cat.No | ADC-37403A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UBR1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Ubr1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IWV7 |
Uniprot Id
Q8IWV7
Target Species
Human
Target Name
UBR1
Target Full Name
E3 ubiquitin-protein ligase UBR1
Target Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Target Involvement
Johanson-Blizzard syndrome (JBS)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
UBR1 family
Target Tissue Specificity
Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Target Synonyms
E3 ubiquitin-protein ligase UBR1; JBS; N-recognin-1; ubiquitin protein ligase E3 component n-recognin 1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I; UBR1; UBR1_HUMAN
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