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The antibody against UNC80 was raised in rabbit using the Recombinant Human Protein unc-80 homolog protein (124-388AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against UNC80 was raised in rabbit using the Recombinant Human Protein unc-80 homolog protein (124-388AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
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Immunofluorescent analysis of HepG2 cells using UNC80 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-11686A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UNC80 |
| Target Synonyms | C2orf21 antibody; Protein unc-80 homolog antibody; UNC 80 antibody; Unc 80 homolog (C. elegans) antibody; Unc80 antibody; UNC80_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein unc-80 homolog protein (124-388AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N2C7 |
Uniprot Id
Q8N2C7
Target Species
Human
Target Name
UNC80
Target Full Name
Protein unc-80 homolog
Target Function
Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.
Target Involvement
Hypotonia, infantile, with psychomotor retardation and characteristic facies 2 (IHPRF2)
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Unc-80 family
Target Tissue Specificity
Moderately expressed in fetal brain, spinal cord, skeletal muscle, thymus, spleen, fetal liver, small intestine, colon, kidney and uterus. Highly expressed in adrenal gland, prostate and testis, as well as in brain and cerebellum.
Target Synonyms
C2orf21; Protein unc-80 homolog; UNC 80; Unc 80 homolog (C. elegans); Unc80; UNC80_HUMAN
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