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The antibody against USP24 was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 2431-2620 of human USP24 (NP_056121.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against USP24 was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 2431-2620 of human USP24 (NP_056121.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01647A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP24 |
| Target Synonyms | USP24 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HT-29, Jurkat, LO2, Mouse lung, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant Protein corresponding to a sequence within amino acids 2431-2620 of human USP24 (NP_056121.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | FTMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP | Uniprot ID | Q9UPU5 |
Uniprot Id
Q9UPU5
Target Species
Human
Target Name
USP24
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 24
Target Function
Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.
Target Protein Families
Peptidase C19 family
Target Synonyms
Deubiquitinating enzyme 24; KIAA1057; Ubiquitin carboxyl terminal hydrolase 24; Ubiquitin carboxyl-terminal hydrolase 24; Ubiquitin specific peptidase 24; Ubiquitin specific processing protease 24; Ubiquitin specific protease 24; Ubiquitin thioesterase 24; Ubiquitin thiolesterase 24; Ubiquitin-specific-processing protease 24; UBP24_HUMAN; Usp24
Target Background
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
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